Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes

H Haraguchi; I Ohmi; S Sakai; A Fukuda; Y Toihara; T Fujimoto; N Okamura; A Yagi

doi:10.1021/np9601622

Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes

J Nat Prod. 1996 Apr;59(4):443-5. doi: 10.1021/np9601622.

Authors

H Haraguchi¹, I Ohmi, S Sakai, A Fukuda, Y Toihara, T Fujimoto, N Okamura, A Yagi

Affiliation

¹ Faculty of Engineering, Fukuyama University, Japan.

PMID: 8699190
DOI: 10.1021/np9601622

Abstract

The sulfated flavonoids in Polygonum hydropiper showed potent inhibiton against lens aldose reductase. Among these flavonoids isorhamnetin 3,7-disulfate (5) was most potent. Kinetic analysis showed that 5 exhibited noncompetitive inhibition against both dl-glyceraldehyde and NADPH.

MeSH terms

Aldehyde Reductase / antagonists & inhibitors*
Animals
Cattle
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Flavonoids / isolation & purification*
Flavonoids / pharmacology
Kidney / enzymology
Lens, Crystalline / enzymology*
Liver / enzymology
Mitochondria, Liver / drug effects
Mitochondria, Liver / enzymology
NADH, NADPH Oxidoreductases / antagonists & inhibitors
Plants, Medicinal / chemistry*
Swine

Substances

Enzyme Inhibitors
Flavonoids
Aldehyde Reductase
NADH, NADPH Oxidoreductases